About CNBI
Mission
To develop nanostructured, biomimetic-interface architectures that express membrane-protein activities and can be used to produce high-value devices and processes.
Background and Objectives
Cell membranes use a bilayer lipid membrane (BLM) and membrane-bound proteins to efficiently perform a diverse array of vital, molecular processes. These processes can be mimicked in vitro by reconstituting membrane proteins into artificial BLM. Recent progress in proteomics allows previously unknown membrane proteins having desired properties to be rapidly identified, cloned, mass produced, and purified.
The State of Michigan MSU has world-class expertise and infrastructure related to membrane proteins. A Michigan Technology Tri-Corridor (MTTC) grant recently established a multi-disciplinary and multi-institutional center or excellence that broadens the scope of this expertise to include both the membrane proteins and the functional interfaces in which they are embedded. This Center for Nanostructured Biomimetic Interfaces (CNBI) consists of 11 researchers from Michigan State University, the Michigan Molecular Institute, and Neogen Corporation who have expertise that spans molecular biology, protein expression, separation science, polymer chemistry, interfacial science, nanotechnology, microelectronics, medicine, and commercial sensing technologies. The initial research objectives of the CNBI are to
- Express and purify recombinant dehydrogenase enzymes, major facilitator subfamily (MFS) transporter proteins, and gated ion channels;
- Develop novel classes of functional biomimetic interfaces containing dehydrogenase enzymes, MFS transporter proteins, and gated ion channels.
- Apply a variety of physical, electrical, and optical methods to measure, and optimize performance properties of the biomimetic interfaces.
- Develop practical devices and processes based on the biomimetic interfaces, including biosensor arrays, for applications in medical and pharmaceutical research.
This research is expected to yield breakthroughs in medicine and the life sciences, as well as new classes of commercial products and processes based on membrane proteins.